The top-ranked team Clemson Tigers are +250 to win their first national championship while Ohio State Buckeyes are the +190 title odds favorites.
Week 5 of the college football season matchup is the ABC prime-time affair and likely Big Ten Game of the Year as No. 4 Ohio State visits No. 9 Penn State.
The best teams in the country will finally get an opportunity to prove themselves in some of the biggest games starting on Friday.
Despite J.T. Barrett ankle injury, the Ohio State Buckeyes was able to win the national championship as dogs in each of their last two games as well.
Two huge rivalry games on Saturday will play a big role in helping shape this year’s College Football Playoff field.
Two highly-ranked Big Ten teams, Ohio State and Penn State, were upset on the road to see their chance at a spot in the national semifinals all but vanish.
Can the second-ranked Penn State Nittany Lions upset the sixth-ranked Ohio State Buckeyes for the second year in a row?
Competitive matchups according to oddsmakers may involve teams residing outside the Top 10 in college football this week.
Much like the NFL this week, college football features some major mismatches with big point spreads favoring very public teams.